SwissProt Database

CYSP_PLAFA

ID   CYSP_PLAFA     STANDARD;      PRT;   569 AA.
AC   P25805;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-NOV-1995 (REL. 32, LAST ANNOTATION UPDATE)
DE   THROPHOZOITE CYSTEINE PROTEINASE PRECURSOR (EC 3.4.22.-) (TCP).
OS   PLASMODIUM FALCIPARUM.
OC   EUKARYOTA; PROTOZOA; APICOMPLEXA; SPOROZOA; COCCIDIA; EUCOCCIDIIDA.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 92228005.
RA   ROSENTHAL P.J., NELSON R.G.;
RL   MOL. BIOCHEM. PARASITOL. 51:143-152(1992).
CC   -!- FUNCTION: PROBABLY DEGRADES ERYTHROCYTE HEMOGLOBIN.
CC   -!- DEVELOPMENTAL STAGE: THROPHOZOITE.
CC   -!- SIMILARITY: BELONGS TO PEPTIDASE FAMILY C1; ALSO KNOWN AS THE
CC       PAPAIN FAMILY OF THIOL PROTEASES.
CC   -!- SIMILARITY: STRONGEST SIMILARITY TO CATHEPSIN L.
DR   EMBL; M81341; G160248; -.
DR   PIR; A45624; A45624.
DR   HSSP; P07858; 1HUC.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS.
DR   PROSITE; PS00640; THIOL_PROTEASE_ASN.
KW   HYDROLASE; THIOL PROTEASE; ZYMOGEN; GLYCOPROTEIN; SIGNAL.
FT   SIGNAL        1      ?       POTENTIAL.
FT   PROPEP        ?    332       ACTIVATION PEPTIDE (POTENTIAL).
FT   CHAIN       333    569       THROPHOZOITE CYSTEINE PROTEINASE.
FT   DOMAIN       64     70       POLY-ASN.
FT   ACT_SITE    357    357       BY SIMILARITY.
FT   ACT_SITE    488    488       BY SIMILARITY.
FT   ACT_SITE    533    533       BY SIMILARITY.
FT   DISULFID    354    395       BY SIMILARITY.
FT   CARBOHYD     58     58       POTENTIAL.
FT   CARBOHYD     98     98       POTENTIAL.
FT   CARBOHYD    121    121       POTENTIAL.
FT   CARBOHYD    127    127       POTENTIAL.
FT   CARBOHYD    479    479       POTENTIAL.
FT   CARBOHYD    487    487       POTENTIAL.
SQ   SEQUENCE   569 AA;  66880 MW;  9B8F0096 CRC32;
     MVAIKEMKEL AFARPSLVET LNKKKKFLKK KEKRTFVLSI YAFITFIIFC IGILYFTNKS
     SAHNNNNNKN EHSLKKEEIE LLRVLLEKYK KQKDGILNES SNEEDEEKYT LNSETYNNKN
     NVSNIKNDSI KSKKEEYINL ERILLEKYKK FINENNEENR KELSNILHKL LEINKLILRE
     EKDDKKVYLI NDNYDEKGAL EIGMNEEMKY KKEDPINNIK YASKFFKFMK EHNKVYKNID
     EQMRKFEIFK INYISIKNHN KLNKNAMYKK KVNQFSDYSE EELKEYFKTL LHVPNHMIEK
     YSKPFENHLK DNILISEFYT NGKRNEKDIF SKVPEILDYR EKGIVHEPKD QGLCGSCWAF
     ASVGNIESVF AKKNKNILSF SEQEVVDCSK DNFGCDGGHP FYSFLYVLQN ELCLGDEYKY
     KAKDDMFCLN YRCKRKVSLS SIGAVKENQL ILALNEVGPL SVNVGVNNDF VAYSEGVYNG
     TCSEELNHSV LLVGYGQVEK TKLNYNNKIQ TYNTKENSNQ PDDNIIYYWI IKNSWSKKWG
     ENGFMRLSRN KNGDNVFCGI GEEVFYPIL