SwissProt Database

CATL_HUMAN

ID   CATL_HUMAN     STANDARD;      PRT;   333 AA.
AC   P07711;
DT   01-APR-1988 (REL. 07, CREATED)
DT   01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE)
DT   01-FEB-1996 (REL. 33, LAST ANNOTATION UPDATE)
DE   CATHEPSIN L PRECURSOR (EC 3.4.22.15) (MAJOR EXCRETED PROTEIN) (MEP).
GN   CTSL.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 88339905.
RA   GAL S., GOTTESMAN M.M.;
RL   BIOCHEM. J. 253:303-306(1988).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 88213715.
RA   JOSEPH L.J., CHANG L.C., STAMENKOVICH D., SUKHATME V.P.;
RL   J. CLIN. INVEST. 81:1621-1629(1988).
RN   [3]
RP   SEQUENCE OF 114-288 AND 292-333.
RX   MEDLINE; 88137635.
RA   RITONJA A., POPOVIC T., KOTNIK M., MACHLEIDT W., TURK V.;
RL   FEBS LETT. 228:341-345(1988).
RN   [4]
RP   SEQUENCE OF 114-155 FROM N.A.
RX   MEDLINE; 87174843.
RA   JOSEPH L., LAPID S., SUKHATME V.;
RL   NUCLEIC ACIDS RES. 15:3186-3186(1987).
RN   [5]
RP   SEQUENCE OF 114-154 AND 292-333.
RX   MEDLINE; 87127952.
RA   MASON R.W., WALKER J.E., NORTHROP F.D.;
RL   BIOCHEM. J. 240:373-377(1986).
CC   -!- FUNCTION: IMPORTANT FOR THE OVERALL DEGRADATION OF PROTEINS IN
CC       LYSOSOMES.
CC   -!- SUBUNIT: DIMER OF AN HEAVY AND A LIGHT CHAIN LINKED BY DISULFIDE
CC       BONDS.
CC   -!- SUBCELLULAR LOCATION: LYSOSOMAL.
CC   -!- SIMILARITY: BELONGS TO PEPTIDASE FAMILY C1; ALSO KNOWN AS THE
CC       PAPAIN FAMILY OF THIOL PROTEASES.
DR   EMBL; X12451; G29715; -.
DR   EMBL; X05256; E12639; -.
DR   EMBL; M20496; G190418; -.
DR   PIR; S01002; KHHUL.
DR   PIR; A26069; A26069.
DR   HSSP; P00784; 1PAD.
DR   MIM; 116880; -.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS.
DR   PROSITE; PS00640; THIOL_PROTEASE_ASN.
KW   HYDROLASE; THIOL PROTEASE; GLYCOPROTEIN; LYSOSOME; ZYMOGEN; SIGNAL.
FT   SIGNAL        1     17       POTENTIAL.
FT   PROPEP       18    113       ACTIVATION PEPTIDE.
FT   CHAIN       114    288       CATHEPSIN L HEAVY CHAIN.
FT   PROPEP      289    291
FT   CHAIN       292    333       CATHEPSIN L LIGHT CHAIN.
FT   ACT_SITE    138    138       BY SIMILARITY.
FT   ACT_SITE    276    276       BY SIMILARITY.
FT   ACT_SITE    300    300       BY SIMILARITY.
FT   DISULFID    135    178       BY SIMILARITY.
FT   DISULFID    169    211       BY SIMILARITY.
FT   DISULFID    269    322       INTERCHAIN (BY SIMILARITY).
FT   CARBOHYD    221    221
FT   CARBOHYD    268    268       (IN REF. 3).
FT   CONFLICT    268    268       D -> N (IN REF. 3).
SQ   SEQUENCE   333 AA;  37564 MW;  BBE9592A CRC32;
     MNPTLILAAF CLGIASATLT FDHSLEAQWT KWKAMHNRLY GMNEEGWRRA VWEKNMKMIE
     LHNQEYREGK HSFTMAMNAF GDMTSEEFRQ VMNGFQNRKP RKGKVFQEPL FYEAPRSVDW
     REKGYVTPVK NQGQCGSCWA FSATGALEGQ MFRKTGRLIS LSEQNLVDCS GPQGNEGCNG
     GLMDYAFQYV QDNGGLDSEE SYPYEATEES CKYNPKYSVA NDTGFVDIPK QEKALMKAVA
     TVGPISVAID AGHESFLFYK EGIYFEPDCS SEDMDHGVLV VGYGFESTES DNNKYWLVKN
     SWGEEWGMGG YVKMAKDRRN HCGIASAASY PTV