SwissProt Database

CATL_CHICK

ID   CATL_CHICK     STANDARD;      PRT;   218 AA.
AC   P09648;
DT   01-MAR-1989 (REL. 10, CREATED)
DT   01-MAR-1989 (REL. 10, LAST SEQUENCE UPDATE)
DT   01-FEB-1996 (REL. 33, LAST ANNOTATION UPDATE)
DE   CATHEPSIN L (EC 3.4.22.15).
OS   GALLUS GALLUS (CHICKEN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; AVES; NEOGNATHAE;
OC   GALLIFORMES.
RN   [1]
RP   SEQUENCE.
RX   MEDLINE; 87304227.
RA   WADA K., TAKAI T., TANABE T.;
RL   EUR. J. BIOCHEM. 167:13-18(1987).
RN   [2]
RP   SEQUENCE OF 1-37 AND 177-216.
RC   TISSUE=LIVER;
RX   MEDLINE; 87080783.
RA   WADA K., TANABE T.;
RL   FEBS LETT. 209:330-334(1986).
RN   [3]
RP   SEQUENCE.
RC   TISSUE=LIVER;
RX   MEDLINE; 88050863.
RA   DUFOUR E., OBLED A., VALIN C., BECHET D., RIBADEAU-DUMAS B.,
RA   HUET J.C.;
RL   BIOCHEMISTRY 26:5689-5695(1987).
CC   -!- FUNCTION: IMPORTANT FOR THE OVERALL DEGRADATION OF PROTEINS IN
CC       LYSOSOMES.
CC   -!- SUBUNIT: DIMER OF AN HEAVY AND A LIGHT CHAIN LINKED BY DISULFIDE
CC       BONDS.
CC   -!- SUBCELLULAR LOCATION: LYSOSOMAL.
CC   -!- SIMILARITY: BELONGS TO PEPTIDASE FAMILY C1; ALSO KNOWN AS THE
CC       PAPAIN FAMILY OF THIOL PROTEASES.
DR   PIR; A26818; KHCHL.
DR   PIR; A25654; A25654.
DR   PIR; S00081; S00081.
DR   HSSP; P00785; 1AEC.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS.
DR   PROSITE; PS00640; THIOL_PROTEASE_ASN.
KW   HYDROLASE; THIOL PROTEASE; GLYCOPROTEIN; LYSOSOME.
FT   CHAIN         1    176       HEAVY CHAIN.
FT   NON_CONS    176    177
FT   CHAIN       177    217       LIGHT CHAIN.
FT   ACT_SITE     25     25       BY SIMILARITY.
FT   ACT_SITE    165    165       BY SIMILARITY.
FT   ACT_SITE    185    185       BY SIMILARITY.
FT   CARBOHYD    109    109
FT   DISULFID     22     65       BY SIMILARITY.
FT   DISULFID     56     99       BY SIMILARITY.
FT   DISULFID    158    207       INTERCHAIN (BY SIMILARITY).
FT   CONFLICT     21     21       Q -> I (IN REF. 3).
FT   CONFLICT     29     29       S -> N (IN REF. 3).
FT   CONFLICT     40     42       RTK -> FKT (IN REF. 3).
FT   CONFLICT     97     98       MISSING (IN REF. 3).
FT   CONFLICT    109    109       N -> K (IN REF. 3).
FT   CONFLICT    177    177       MISSING (IN REF. 3).
FT   CONFLICT    197    197       I -> Q (IN REF. 3).
SQ   SEQUENCE   218 AA;  23963 MW;  9CD1C0FF CRC32;
     APRSVDWREK GYVTPVKDQG QCGSCWAFST TGALEGQHFR TKGKLVSLSE QNLVDCSRPE
     GNQGCNGGLM DQAFQYVQDN GGIDSEESYP YTAKDDEDCR YKAEYNAAND TGFVDIPQGH
     ERALMKAVAS VGPVSVAIDA GHSSFQFYQS GIYYEPDCSS EDLDHGVLVV GYGFEGGKKY
     WIVKNSWGEK WGDKGYIYMA KDRKNHCGIA TAASYPLV